Sulfadiazine silver
Silvadene, Ssd, Thermazene (sulfadiazine, silver) is a small molecule pharmaceutical. Sulfadiazine, silver was first approved as Silvadene on 1982-01-01.
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Clinical Trials
108 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Burns | D002056 | — | T30.0 | — | 5 | 4 | 5 | 10 | 23 |
| Hearing loss | D034381 | EFO_0004238 | H91.9 | — | — | — | 1 | 12 | 13 |
| Deafness | D003638 | EFO_0001063 | H91.9 | — | — | — | 1 | 12 | 13 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | 2 | — | 1 | 4 | 7 |
| Infections | D007239 | EFO_0000544 | — | 1 | 2 | — | 1 | — | 3 |
| Communicable diseases | D003141 | — | — | 1 | 2 | — | 1 | — | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 1 | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | 1 | — | 1 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | — | — | — | 1 | — | 1 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatic encephalopathy | D006501 | — | K72.91 | — | 1 | 2 | — | — | 3 |
| Brain diseases | D001927 | — | G93.40 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Radiodermatitis | D011855 | — | L58 | — | 2 | — | — | 2 | 4 |
| Somatoform disorders | D013001 | — | F45 | — | 1 | — | — | 3 | 4 |
| Colonic neoplasms | D003110 | — | C18 | — | 1 | — | — | 1 | 2 |
| Rectal neoplasms | D012004 | — | — | — | 1 | — | — | 1 | 2 |
| Dermatitis | D003872 | — | L30.9 | — | 2 | — | — | — | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | 1 | 2 |
| Uterine cervical neoplasms | D002583 | — | — | — | 1 | — | — | 1 | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | 1 | — | — | — | — | 1 |
| Hepatitis b | D006509 | — | — | 1 | — | — | — | — | 1 |
| Hepatitis | D006505 | — | K75.9 | 1 | — | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | — | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Unilateral hearing loss | D046088 | — | — | — | — | — | — | 7 | 7 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | — | — | 5 | 5 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 5 | 5 |
| Speech sound disorder | D066229 | — | — | — | — | — | — | 3 | 3 |
| Conductive hearing loss | D006314 | — | H90.2 | — | — | — | — | 3 | 3 |
| Medically unexplained symptoms | D000071896 | — | — | — | — | — | — | 3 | 3 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 3 | 3 |
| Mixed conductive-sensorineural hearing loss | D046089 | — | H90.8 | — | — | — | — | 2 | 2 |
| Fibrosis | D005355 | — | — | — | — | — | — | 2 | 2 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sulfadiazine silver |
| INN | — |
| Description | Silver(1+) sulfadiazinate is a silver salt, a sulfonamidate and a member of pyrimidines. It has a role as an antimicrobial agent and an antibacterial drug. It contains a sulfadiazinate. |
| Classification | Small molecule |
| Drug class | antimicrobials (sulfonamides derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ccc(S(=O)(=O)[N-]c2ncccn2)cc1.[Ag+] |
Identifiers
| PDB | — |
| CAS-ID | 22199-08-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1382627 |
| ChEBI ID | 9142 |
| PubChem CID | 441244 |
| DrugBank | DB05245 |
| UNII ID | — |
Target
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Estimated US medical usage
Sulfadiazine silver
+
Silver sulfadiazine
Total medical expenditures per year (USD, in millions)
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Safety
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907 adverse events reported
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